Targeting of ews-fli1 as anti-tumor therapy

Details Targeting of ews-fli1 as anti-tumor therapy Targeting of ews-fli1 as anti-tumor therapy

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 31/404 (2006.01) A61K 31/4439 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61P 35/00 (2006.01) C07D 209/34 (2006.01) C07D 401/06 (2006.01) C07K 7/06 (2006.01)

Patent

CA 2711003

Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

La présente invention concerne des peptides et composés qui agissent comme inhibiteurs de la protéine EWS-FLI1. Ces peptides et composés conviennent pour le traitement de tumeurs de la famille des sarcomes d'Ewing. L'invention concerne également des procédés d'élaboration des composés et des essais pour l'identification d'inhibiteurs de la protéine EWS-FLI1.

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