Targeting of therapeutic agents using polysaccharides

Details Targeting of therapeutic agents using polysaccharides Targeting of therapeutic agents using polysaccharides

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2097589

The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor. and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME.

L'invention concerne une méthode pour diriger un agent thérapeutique vers une population précise de cellules, consistant en la formation d'un complexe entre l'agent thérapeutique et un polyoside capable d'interagir avec un récepteur de la cellule. Le complexe résultant pénètre dans la cellule par endocytose assistée par le récepteur (RME). Dans un modèle de l'invention, un complexe peut se former entre un agent thérapeutique contenant du fer et le polyoside arabinogalactane et servir à acheminer du fer plus particulièrement aux cellules hépatiques par RME.

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