Targeting opposite strand replication intermediates of...

Details Targeting opposite strand replication intermediates of... Targeting opposite strand replication intermediates of...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01)

Patent

CA 2581224

The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.

L'invention concerne des méthodes et des compositions servant à moduler la réplication virale par l'intermédiaire d'une extinction de gène médiée par un ARN monocaténaire (ARNi), ces méthodes et ces compositions antivirales ciblant, de préférence, des intermédiaires de réplication de brins opposés de virus d'ARN monocaténaire.

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