A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/30 (2006.01) A61K 38/18 (2006.01) A61P 17/02 (2006.01)
Patent
CA 2755786
Methods of screening or designing therapeutic agents effective for the treatment of a transglutaminase-associated disease, disorder and/or condition are provided which include determining whether a candidate agent can modulate an interaction between a transglutaminase and an insulin-like growth factor and/or a member of the IGF family of receptors. Also provided are pharmaceutical compositions and methods of treatment using said pharmaceutical compositions.
La présente invention concerne des procédés de criblage ou de conception d'agents thérapeutiques efficaces pour le traitement d'une maladie, d'un trouble et/ou d'une condition associés aux transglutaminases, qui comprennent la détermination du fait qu'un agent candidat peut ou non moduler une interaction entre une transglutaminase et un facteur de croissance de type insuline et/ou un membre de la famille des récepteurs des IGF. La présente invention concerne en outre des compositions pharmaceutiques et des procédés de traitement utilisant lesdites compositions pharmaceutiques.
Croll Tristan
Peet Jesse
Rizzi Simone
Shooter Gary Keith
Upton Zee
Moffat & Co.
Queensland University Of Technology
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