A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2520987
The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.
La présente invention porte sur des procédés de traitement des cancers par manipulation d'une expression génique cible par sur-régulation, silençage et/ou sous-régulation du gène, tel que EGFR-RP, TRA1, MFGE8, TNFSF13 et ZFP236, respectivement. Les procédés sont utiles dans le traitement des cancers et/ou l'inhibition de la croissance tumorale par renforcement de l'expression d'un gène qui est validé comme une cible telle que ICT1030, pour une protéine, un médicament peptidique et des modalités de thérapie génique; ou par l'interférence de l'ARN pour silencer et/ou sous-réguler des cibles telles que ICT1024, ICT1025 et ICT1031 et ICB1003 qui sont validées pour un anticorps, une petite molécule et autres modalités de médicaments inhibiteurs.
Liu Yijia
Lu Patrick Y.
Tang Quinn Q.
Woodle Martin C.
Xie Frank Y.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Intradigm Corporation
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