C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/04 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2657640
The present invention provides a tartrate salt of Formula (I), Formula I is also known as (7S)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2R)-2-methylpiperazin-1-yl]-6,7-dihydro-5H-cyclopenta[b]pyridine. The tartrate salt is preferably crystalline. The tartrate salt of Formula I of the invention is useful in the treatment of diseases linked to activation of the 5HT2c receptor in animals including humans, for example, in the treatment of schizophrenia, cognitive deficits including cognitive deficits associated with schizophrenia, anxiety, depression, obsessive-compulsive disorder, epilepsy, obesity, sexual dysfunction, and urinary incontinence, among others.
L'invention concerne un sel de tartrate de formule (I), formule (I) également désignée par (7S)-7-[(5-fluoro-2-méthyl-benzyl)oxy]-2-[(2R)-2- méthylpipérazin -1-yl]-6,7-dihydro -5H-cyclopenta[b]pyridine, ce sel de tartrate étant de préférence cristallin. Le sel de tartrate de formule (I) de l'invention est utile dans le traitement de maladies liées à l'activation du récepteur 5HT2c chez les animaux et les humains, par exemple, pour le traitement de la schizophrénie, de déficits cognitifs y compris de déficits cognitifs associés à la schizophrénie, de l'anxiété, de la dépression, de troubles obsessionnels-compulsifs, de l'épilepsie, de l'obésité, de dysfonctionnements sexuels et de l'incontinence urinaire, entre autres.
Liu Kevin Kun-Chin
Zeng Yuan
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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