C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/08 (2006.01) A61K 31/495 (2006.01) A61P 25/34 (2006.01) C07D 221/00 (2006.01)
Patent
CA 2447405
The present invetion is directed to the tartrate salts of 5,8,14- triazatetracyclo[10.3.1.02,11.04,9]-hexadeca-2(11),3,5,7,9-pentaene of formula (1), and pharmaceutical compositions thereof. The present invetion in particular is directed to the L-tartrate salt, and further to the various polymorphs of the L-tartrate salt, including two distinct anhydrous polymorphs (referred to herein as Forms A and B) and a hydrate polmorph (referred to hrein as Form C). In addition, the present invention is also directed to the D- tartrate salt of 5,8,14-triazatetracyclo[10.3.1.02,11.04,9]-hexadeca- 2(11),3,5,7,9-pentaene and the various polmorphs tereof; as well as the D,L- tartrate salt thereof and its polymorphs, and the meso-tartrate salt thereof and its polymorphs.
La présente invention concerne des sels de tartrate de 5,8,14-triazatétracyclo[10.3.1.0?2,11¿.0?4,9¿]-hexadéca-2(11),3,5,7,9-pentaène de formule (1), et de leurs compositions pharmaceutiques. La présente invention a trait particulièrement au sel de L-tartrate, ainsi qu'aux diverses formes polymorphes du sel de L tartrate, comprenant deux formes polymorphes anhydres distinctes (désignées ici Formes A et B) et une forme polymorphe hydrate (désignée ici Forme C). En outre, la présente invention a trait également au sel de D-tartrate de 5,8,14-triazatétracyclo[10.3.1.0?2,11¿.0?4,9¿]- hexadéca-2(11),3,5,7,9-pentaène et ses diverses formes polymorphes, ainsi que son sel de D,L tartrate et ses polymorphes, et son sel de méso-tartrate et ses formes polymorphes.
Bogle David Everett
Rose Peter Robert
Williams Glenn Robert
Pfizer Products Inc.
Smart & Biggar
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