C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/94 (2006.01) A61K 31/165 (2006.01) A61K 31/194 (2006.01) A61K 31/517 (2006.01) A61K 47/40 (2006.01) A61P 35/00 (2006.01) C07C 59/255 (2006.01) C07C 259/06 (2006.01)
Patent
CA 2698944
The present invention relates to tartrate salts or complexes of quinazoline containing zinc-binding moiety based derivatives that are inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and their use in the treatment of EGFR-TK related diseases and disorders such as cancer. The tartrate salts or complexes may further act as HDAC inhibitors.
La présente invention concerne des dérivés, à base de sels de type tartrates ou de complexes de quinazoline contenant un groupe fonctionnel liant le zinc, d'inhibiteurs de la tyrosine kinase du facteur de croissance épidermique (EGFR-TK, de l'anglais epidermal growth factor receptor tyrosine kinase) et leur utilisation dans le traitement de maladies associées à l'EGFR-TK, ainsi que d'affections telles que le cancer. Les sels de type tartrates ou les complexes peuvent, en outre, agir en tant qu'inhibiteurs de l'HDAC.
Cai Xiong
Qian Changgeng
Zhai Haixiao
Curis Inc.
Gowling Lafleur Henderson Llp
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