Taste masked liquid suspensions

Details Taste masked liquid suspensions Taste masked liquid suspensions

A - Human Necessities

61

K

A61K 47/30 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 45/08 (2006.01)

Patent

CA 2253811

The present invention relates to a taste-masked pharmaceutical composition. In particular the invention relates to suspensions of microcapsules taste-masked as a function of a polymer coating and the pH of a suspending medium. Surprisingly, a polymer considered permeable maintains taste masking in this media whereas a polymer considered impervious by the industry does not. There is provided a taste masked oral pharmaceutical composition including: a pharmaceutically active ingredient having a pH-dependent solubility; a polymer encapsulating said pharmaceutically active ingredient, said polymer having a quaternary ammonium functionality; a suspending medium for suspending the encapsulated pharmaceutically active ingredient, said medium adjusted to a predetermined pH at which the pharmaceutically active ingredient remains substantially insoluble; and wherein the pharmaceutically active ingredient is taste masked by the combination of the polymer and suspending medium.

L'invention porte sur une composition pharmaceutique à goût masqué, et en particulier sur des suspensions de microcapsules à goût masqué du fait de leur enrobage polymère et du pH du milieu de suspension. On a constaté avec surprise qu'un polymère considéré comme perméable conserve le masquage de goût dans un tel milieu, alors qu'un polymère considéré comme imperméable par la profession ne le conserve pas. L'invention porte donc sur une composition pharmaceutique orale à goût masqué comportant un principe actif dont la solubilité dépend du pH; sur un polymère d'enrobage dudit principe actif possédant une valence fonctionnelle d'ammonium quaternaire; sur un milieu de suspension du principe actif enrobé, placé à un pH prédéterminé auquel le principe actif reste sensiblement insoluble. Dans cette composition, le principe actif est masqué par l'association du polymère et du milieu de suspension.

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