A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01)
Patent
CA 2549539
The present invention discloses a substantially amorphous pharmaceutical composition comprising a drug that can exist in a variety of polymorphic forms and a pH sensitive polymer, which inhibits the crystallization of the drug during formulation and reconstitution. Polymers of higher molecular weight are more effective at lower loading, especially when the drug polymer matrix is prepared by the solvent evaporation or solvent extraction technique. The composition used as dry syrups maintain bioavailability of the drug and effectively mask the taste of the drug when the composition is reconstituted.
La présente invention a trait à une composition pharmaceutique sensiblement amorphe comportant un médicament qui peut se présenter sous diverses formes polymorphes et un polymère sensible au pH, qui assure l'inhibition de la cristallisation du médicament lors de la formulation et de la reconstitution. Les polymères à poids moléculaire élevé sont plus efficaces à une charge inférieure, notamment lorsque la matrice polymérique du médicament est préparée par la technique d'évaporation de solvant ou d'extraction de solvant. Les compositions utilisées sous la forme de sirops secs préservent la biodisponibilité du médicament et assurent le masquage efficace du goût du médicament lors de la reconstitution de la composition.
Kulkarni Mohan Gopalkrishna
Menjoge Anupa Ramesh
Council Of Scientific & Industrial Research
Sim & Mcburney
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