Taste-masking vehicle for coated oxazolidinone particles

Details Taste-masking vehicle for coated oxazolidinone particles Taste-masking vehicle for coated oxazolidinone particles

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2519869

The present invention is directed to dry formulations of coated oxazolidinone particles, such as coated linezolid particles, which, when suspended in an aqueous solution, mask the taste of the oxazolidinone in the resulting suspension vehicle. Specifically, a mixture of sugars in the formulation, comprising sorbitol and sucrose, inhibit mass transport of the oxazolidinone from the particles into the suspension vehicle. Dry formulations of the coated oxazolidinone particles, suspensions of the same, and methods of using the same to treat or prevent infections from gram positive bacteria are all disclosed.

La présente invention se rapporte à des formulations sèches de particules d'oxazolidinone enrobées, telles que des particules de linézolide enrobées qui, lorsqu'elles sont mises en suspension dans une solution aqueuse, masquent le goût de l'oxazolidinone dans l'excipient de suspension obtenu. De préférence, un mélange de sucres dans ladite formulation, comprenant du sorbitol et de la saccharose, inhibent le transfert en masse de l'oxazolidinone depuis les particules dans l'excipient de suspension. Des formulations sèches des particules d'oxazolidinone enrobées, des suspensions les contenant et des procédés permettant de les utiliser pour traiter ou prévenir des infections par bactéries gram positif sont tous divulgués.

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