C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 303/22 (2006.01) A61K 31/185 (2006.01) A61K 31/195 (2006.01)
Patent
CA 2312842
Compositions, syntheses, formulations and methods for treating or protecting the retina of a mammalian eye by contacting, with the retinal tissue, a therapeutically effective amount of retinyliden tauret (3,7-dimethyl-9-(2,6,6-trimehyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-imido- (N-ethane sulfonic acid)). The invention includes methods for synthesizing two (2) specific isomers of retinyliden tauret, namely (A) all-trans-[3,7-dimethyl-9-(2,6,6-trimehyl-1-cyclohexen-1-yl)-2,4,6,8- nonatetraen-1-imido-(N-ethane sulfonic acid)] and (B) 11-cis-[3,7-dimethyl-9-(2,6,6-trimehyl-1-cyclohexen-1-yl)-2,4,6,8- nonatetraen-1-imido-(N-ethane sulfonic acid)]. Also included are formulations and methods for administering such compounds to the retina of a mammalian eye to treat or prevent the progression or retinopathy.
L'invention porte sur des compositions, synthèses, préparations et procédés de traitement ou de protection de la rétine de l'oeil de mammifères consistant à mettre en contact une dose à effet thérapeutique de tauret de rétinylidène, acide (3,7-diméthyl-9-(2,6,6-triméthyl-1-cyclohexène-1-yl)-2,4,6,8-nonatétraen-1imido-(N-éthane sulfonique). L'invention comprend des procédés de synthétisation de deux isomères spécifiques de la tauret de rétinylidène c.-à-d. (A) soit l'acide tout-trans [3,7-diméthyl-9-(2,6,6-triméthyl-1-cyclohexène- 1-yl)-2,4,6,8- nonatétraen-1imido- (N-éthane sulfonique)], et (B) l'acide 11-cis[3,7-diméthyl-9-(2,6,6-triméthyl-1-cyclohexène-1-yl)-2,4,6,8-nonatétraen-1imido-(N-éthane sulfonique)]. L'invention porte également sur des préparations et méthodes d'administration desdits composés à la rétine d'un oeil de mammifère pour traiter ou prévenir la progression de la rétinopathie.
Haroutounian Jasmine E.
Petrosian Andranik M.
Vartanian Armen
Gowling Lafleur Henderson Llp
Karageozian Hampar
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