Taxane derivatives, their preparation and use in oncology

Details Taxane derivatives, their preparation and use in oncology Taxane derivatives, their preparation and use in oncology

C - Chemistry, Metallurgy

07

C

C07C 69/618 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) C07C 69/00 (2006.01) C07C 233/87 (2006.01) C07C 271/22 (2006.01)

Patent

CA 2091002

The preparation of new 3,11-cyclotaxanes having the general formula I. Image wherein each of R' and R", independently of the other, is hydrogen, alkanoyl of 2 to 7 carbon atoms, -CO- CHOHCH(C6H5)NHCOC6H5, or -COCHOHCH(C6H5)NHCOOC(CH3)3. Cyclotaxane 1a (1, R'=R"=H) may be isolated from plants of the genus Taxus. New cyclotaxanes 1 have antiblastic activity.

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