Taxane having antitumor activity

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 305/14 (2006.01) A61K 31/335 (2006.01)

Patent

CA 2140519

The present invention relates to a new taxane having the structure (1), which is isolatable from root bark of plants of the Taxus genus. The compound (1) is endowed with antitumor activity higher than the one of taxol, the former being active, unlike hte latter, also against adriamicine resistant cells and as antileukemic drug.

La présente invention concerne une nouvelle taxane possédant la structure (1) qui est isolée de l'écorce des racines des plantes de l'espèce Taxus. Le composé (1) est pourvu d'une activité anti-tumeur plus importante que celle du taxol, car il est actif, contrairement à ce dernier, contre les cellules résistant à l'adriamicyne et comme agent antileucémique.

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