Taxane prodrugs

Details Taxane prodrugs Taxane prodrugs

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2384646

The present invention generally provides taxane prodrugs comprising at least one taxane joined by hydrolyzable bond(s) to one or more polyethylene glycol oligomer(s) selected from the group consisting of a straight or branched polyethylene glycol oligomer having from 1 to 25 polyethylene glycol units and optionally comprising a salt-forming moiety. The polyethylene glycol oligomer preferably comprises a salt-forming moiety, which is preferably selected from the group consisting of ammonium and carboxylate.

L'invention concerne d'une manière générale des promédicaments à base de taxane renfermant au moins un taxane rattaché par une ou plusieurs liaisons hydrolysables à un ou plusieurs oligomères de polyéthylèneglycol pouvant être un oligomère de polyéthylèneglycol linéaire ou ramifié qui comporte entre 1 et 25 unités de polyéthylèneglycol et éventuellement une fraction salifiable. De préférence, l'oligomère de polyéthylèneglycol comporte une fraction salifiable, cette fraction étant de préférence ammonium ou carboxylate.

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