Taxoid derivative and method of producing thereof

Details Taxoid derivative and method of producing thereof Taxoid derivative and method of producing thereof

C - Chemistry, Metallurgy

07

H

C07H 15/26 (2006.01) C07H 15/04 (2006.01)

Patent

CA 2206739

A taxoid derivative wherein sugar is combined with any one of paclitaxel, docetaxel and 10-deacetyl-bacatin III via a spacer. A method of producing the taxoid derivative comprises protecting hydroxyl groups at specific position of paclitaxel or docetaxel by protective compound followed by reacting with tetrabenzyl acetyloxyglucoside, and then carrying out debenzyl and detriethylsilyl reactions. A method of producing the taxoid derivative comprises reacting paclitaxel or docetaxel with tetrabenzyl acetyloxyglucoside, and then carrying out debenzyl reaction.

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