Taxol derivatives

Details Taxol derivatives Taxol derivatives

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/41 (2006.01) A61K 31/495 (2006.01) A61K 31/665 (2006.01) C07D 405/12 (2006.01) C07D 407/02 (2006.01) C07D 409/04 (2006.01) C07D 413/02 (2006.01) C07D 417/04 (2006.01) C07F 9/655 (2006.01)

Patent

CA 2165079

A compound or prodrug thereof having formula (II), wherein -OR1 comprises the C-13 side-chain of taxol and Z is selected from the group consisting of -CHO, -CH2OH, -CH2OR', -CH2NR'R", -CH=NR', -CH=NOR', -CH=NNR'R", -CH(OH)SO3Na, -CH2OPO3=, -CH2OSO3=, -CN and a radical of formula (a) where X and Y are independently selected from -O-, -S-, and -N(R')-, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same.

Composé ou promédicament de ce dernier, répondant à la formule (II), dans laquelle -OR<1> comprend la chaîne latérale C-13 de taxol et Z est choisi dans le groupe composé de -CHO, -CH2OH, -CH2OR', -CH2NR'R", -CH=NR', -CH=NOR', -CH=NNR'R", -CH(OH)SO3Na, -CH2OPO3<=>, -CH2OSO3<=>, -CN, et d'un radical de la formule (a) dans laquelle X et Y sont indépendament choisis entre -O-, -S-, et -N(R')-. L'invention se rapporte également à un procédé de préparation des composés de l'invention, à un procédé destiné à leur utilisation pour inhiber des tumeurs ainsi qu'à des compositions pharmaceutiques les contenant.

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