Tc-83-derived alphavirus vectors, particles and methods

Details Tc-83-derived alphavirus vectors, particles and methods Tc-83-derived alphavirus vectors, particles and methods

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/12 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2567254

The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.

Sont dévoilés ici des réplicons dérivés du TC-83 EEV, des particules de réplicon alpha viral et des composés immunogènes contenant des particules de réplicon alpha viral TC-83 qui déterminent l~expression d~au moins un antigène lorsqu~elles sont introduites dans des cellules hôtes appropriées. Les PRA dérivées du TC-83 VEE décrites ici sont améliorées en ce qu~elles sont sujettes à une réaction immunitaire englobant un plus grand nombre de vecteurs que les précédentes PRA.

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