Tc(iii)myocardial imaging agents and method of use

Details Tc(iii)myocardial imaging agents and method of use Tc(iii)myocardial imaging agents and method of use

C - Chemistry, Metallurgy

07

F

C07F 13/00 (2006.01) A61K 51/04 (2006.01) C07B 59/00 (2006.01) C07C 225/14 (2006.01) C07D 307/56 (2006.01) C07F 9/50 (2006.01) C07F 9/655 (2006.01) A61K 49/02 (1990.01)

Patent

CA 2097081

2097081 9211040 PCTABS00014 A myocardial imaging agent for use in humans comprising a TC(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanome rings and in the axial positions by phosphines containing dioxanyl or ether moieties. The agent exhibits improved biodistribution, improved labeling and extremely rapid blood clearance following administration to a human. The agent has high myocardial uptake accompanied with exceptionally rapid hepatobilary clearance and extensive renal clearance to give sufficiently high heart/liver and heart/lung ratio that provide nearly ideal myocardial images in humans.

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