C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/309.3, 260/5
C07D 277/82 (2006.01) A61K 51/04 (2006.01) C07D 265/32 (2006.01)
Patent
CA 1230342
16757 TITLE OF THE INVENTION Tc99m-PHENIDA, RADIOSCINTIGRAPHIC AGENT FOR DIAGNOSIS OF HEPATOBILIARY DISEASE ABSTRACT OF THE DISCLOSURE This invention relates to novel derivatives of imino diacetic acid of the formula: Image wherein R1 is selected from the group consisting of: Image - 2 - 16757 Image wherein X is halo (chloro, bromo or iodo) and R2 is lower alkyl of from 1-5 carbon atoms. It also relates to a novel diagnostic kit for heptaobiliary imaging comprising ingredients employed in the intravenous injection of a complex of technetium 99m, and an imino diacetic acid of the above formula. It also relates to a Process for preparing said compounds by reaction of nitrilotriacetic acid anhydride and an amine of the formula R1NH2 wherein R1 is as defined hereinabove.
434827
Goudreau Gage Dubuc
Merck Frost Canada Inc.
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