C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2183856
The present invention relates to TCF mutant having a novel amino acid sequence which is obtained by mutagenesis of one or more amino acid between N-terminus and the first kringle of the amino acid sequence of native TCF and has lowered affinity to heparin and/or elevated biological activity. The present TCF mutant is prepared by gene manipulation of TCF. The TCF mutants of the present invention have proliferative activity and/or growth stimulative activity in hepatocyte and beneficial as a therapeutic agent for, various hepatic diseases and an antitumor agent.
Mutant de TCF possédant une nouvelle séquence d'acides aminés, qui est obtenu par mutagenèse d'un ou plusieurs acides aminés contenus dans un domaine allant de la terminaison N au premier kringle de la séquence d'acides aminés de TCF naturel et qui possède une affinité affaiblie pour l'héparine et/ou une activité biologique élevée. Ledit mutant de TCF, qui est préparé par manipulations géniques à l'aide de TCF, est capable de faire proliférer des cellules parenchymateuses hépatiques et/ou de favoriser la prolifération desdites cellules, et est utile comme remède pour diverses maladies du foie et comme agent antitumoral.
Goto Masaaki
Higashio Kanji
Kinosaki Masahiko
Kobayashi Fumie
Murakami Akihiko
Atlas Pharmaceuticals Inc.
Dennison Associates
Snow Brand Milk Products Co. Ltd.
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