Tcl-1b gene and protein and related methods and compositions

Details Tcl-1b gene and protein and related methods and compositions Tcl-1b gene and protein and related methods and compositions

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 17/00 (2006.01) C07K 17/02 (2006.01) C07K 17/04 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2367906

The TCLI gene family, located on the human chromosome at the 14q32.1 locus, are implicated in the development of T-cell malignancies. The present invention discloses the identification and characterization of a new member of this gene family, the TCL-1b gene. The TCL-1b gene sequence is expressed at very low levels in normal bone marrow and peripheral lymphocytes, but is activated in T-cell leukemia and lymphoma by rearrangements of the 14q32.1 locus. The present invention relates to the identification of these chromosome 14 abnormalities, and methods for detecting and treating any T-cell malignancies that develop, as well as preventing the development of these T-cell malignancies.

Les gènes de la famille TCL1, situés sur le chromosome humain au locus 14q32.1, sont impliqués dans le développement des malignités des lymphocytes T. L'invention se rapporte à l'identification et la caractérisation d'un nouvel élément de cette famille de gènes, le gène TCL-1b. La séquence de gènes TCL-1b s'exprime à de très faibles niveaux dans la moelle osseuse normale et dans les lymphocytes périphériques, mais elle s'active dans la leucémie lymphocytaire et les lymphomes par réorganisation du locus 14q32.1. La présente invention se rapporte, d'une part à l'identification de ces anomalies du chromosome 14, et d'autre part à la détection et au traitement des malignités en cours de développement, ainsi qu'à la prévention du développement de ces malignités des lymphocytes T.

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