Tcr-v-beta related peptides for treatment and diagnosis of...

Details Tcr-v-beta related peptides for treatment and diagnosis of... Tcr-v-beta related peptides for treatment and diagnosis of...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12P 21/08 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01) C07K 14/725 (2006.01)

Patent

CA 2618796

There are provided peptides derived from antibodies with reactivity against a GPI linkage epitope and functionally-equivalent ligands. These peptides can be used in the therapy and diagnosis of a variety of diseases, all of which are considered to be caused by the inappropriate presence in the body of autoantibodies which are reactive with GPI linkage epitopes. There is also described a mechanism of action of these autoantibodies which compromises the organism, so causing disease, and a method of prevention of disease and detection of the autoantibody.

L'invention concerne des peptides dérivés d'anticorps présentant une réactivité contre un épitope de liaison GPI et des ligands fonctionnellement équivalents. Ces peptides peuvent servir au traitement et au diagnostic de diverses pathologies, qui sont toute considérées comme résultant de la présence inappropriée dans l'organisme d'auto-anticorps réagissant avec les épitopes de liaison GPI. L'invention porte en outre sur le mécanisme d'action de ces auto-anticorps, qui porte atteinte à l'organisme, et cause ainsi une pathologie, et sur une méthode de prévention des pathologies et de détection de ces anto-anticorps.

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