C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/48, 260/428.
C07F 13/00 (2006.01) A61K 51/00 (2006.01) A61K 51/04 (2006.01)
Patent
CA 2002850
The invention relates to a technetium-99m complex of the general formula (see above formula) wherein -Z is a sulphur atom or an amino group of the general formula R17-N-(R18)k, in which k is 0 or 1 and R17 and R18 have the same meanings as the symbols R1-R16; - each of the symbols R1-R16 is individually selected from the group consisting of hydrogen, straight or branched, unsubstituted or substituted alkyl having 1-4 carbon atoms, and ACOOH, wherein A is a straight or branched, unsubstituted or substituted alkyl group having 0-4 carbon atoms; and R5 together with R6 or R7 together with R10 additionally may form an oxygen atom; -Tc represents technetium-99m; -t is 0 or 1; and -n is 0 or 1; with the provisos that (a) if R15, R16, R17 and/or R18 are/is ACOOH, A is a straight or branched, unsubstituted or substituted alkyl group having 1-4 carbon atoms; (b) at least one of the symbols R1-R18 is ACOOH; and (c) if t is 1, at least two of the symbols R1-R18 are ACOOH; or a pharmaceutically acceptable salt of this compound. The invention further relates to a radiopharmaceutical composition comprising said complex, to the use of this composition far examining the renal function, and to a kit for preparing such a composition.
Nosco Dennis L.
Verbruggen Alfons M.
Mallinckrodt Inc.
Nosco Dennis L.
Osler Hoskin & Harcourt Llp
Verbruggen Alfons M.
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