Technetium- and rhenium- bis (heteroaryl) complexes and...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/38 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07C 275/24 (2006.01)

Patent

CA 2745955

A compound of Formula (I), a phar-maceutically acceptable salt, or solvate thereof, com-plexes with metals such as rhenium, technetium, and others to provide a complex for imaging tissues or treating disease, particularly where the metal is ra-dioactive. Such complexes are specific to PSMA protein and can therefore be used in imaging or treat-ing cancer of the prostate and other tissue where the protein is expressed.

L'invention porte sur un composé de Formule (I), sur un sel pharmaceutiquement acceptable ou un solvate de celui-ci, sur des complexes avec des métaux tels que le rhénium, le technétium et autres pour fournir un complexe pour l'imagerie de tissus ou le traitement d'une maladie, en particulier si le métal est radioactif. De tels complexes sont spécifiques à la protéine PSMA et peuvent par conséquent être utilisés dans l'imagerie ou le traitement d'un cancer de la prostate et d'un autre tissu où la protéine est exprimée.

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