C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/38 (2006.01) A61K 51/04 (2006.01) C07C 229/06 (2006.01) C07D 217/14 (2006.01)
Patent
CA 2555963
One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluoresence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.
Un aspect de l'invention concerne des complexes de technétium (Tc) et de rhénium (Re) comprenant différents ligands hétéroaromatiques, par exemple, des ligands quinolinyle et isoquinolinyle, et leur utilisation dans la fluorescence et l'imagerie radio pour différentes applications diagnostiques cliniques ainsi que des produits radiopharmaceutiques destinés à des applications thérapeutiques. Un autre aspect de l'invention concerne des ligands quinolinyle et isoquinolinyle qui forment une partie des complexes mentionnés. L'invention concerne également des méthodes de préparation des complexes de technétium et de rhénium. Un autre aspect de l'invention concerne des ligands quinolinyle et isoquinolinyle à base de lysine, d'alanine et de bis-amino acides dérivés destinés à être conjugués à des petits peptides à l'aide de méthodes synthétiques en phase solide. L'invention concerne en outre des procédés permettant de mettre en image des zones d'un mammifère à l'aide des complexes selon l'invention.
Babich John
Eckelman William C.
Maresca Kevin P.
Valliant John F.
Zubieta Jon
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mcmaster University
Molecular Insight Pharmaceuticals
National Institutes Of Health
Syracuse University
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