Technetium- and rhenium-bis(heteroaryl) complexes and...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/38 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07F 13/00 (2006.01)

Patent

CA 2745918

Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide. The bioactive molecule may be a peptide or somatostatin.

Selon l'invention, des complexes de radionucléides hétérocycliques sont préparés sur la base de ligands comportant des groupes pyridyle et imidazolyle substitués. Les ligands sont bifonctionnels, comportant des résidus d'acides aminés qui peuvent agir en tant que lieur avec une molécule bioactive, et un chélateur tridenté qui peut complexer le radionucléide. La molécule bioactive peut être un peptide ou une somatostatine.

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