C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
167/48, 530/5.08
C07K 5/08 (2006.01) A61K 51/04 (2006.01) C07F 13/00 (2006.01)
Patent
CA 1316296
CIL 0132 ABSTRACT: The invention relates to a technetium chelate of the general formula Image (I) wherein X is a sulphur atom or an imino group, Z is a hydrogen atom, a carboxy group, an alkoxycarbo- nyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho group, an aminosulphonyl group or a carboxymethylaminocarbonyl group, Tc represents technetium-99m, R1 is a hydrogen atom or an alkyl group having 1 or 2 carbon atoms, and R2, R3, R4 and R5 are equal or different and re- present hydrogen atoms or branched or non-branched alkyl groups having 1-4 carbon atoms, which alkyl groups are optionally substituted with an amino group, a hydroxy group, a mercapto group, a halogen atom, a carboxy group or an aminocarbonyl group, with the proviso that R3, R4 and R5 do not all three of them represent hydrogen atoms; as well as water-soluble salts of these compounds. CIL 0132 The invention also relates to a tripeptide compound to be used for preparing said chelate and to a kit comprising a composition of said tripeptide compound.
537923
Mallinckrodt Inc.
Osler Hoskin & Harcourt Llp
Verbruggen Alfons M.
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