Telomelysin-gfp gene-containing recombinant virus

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/04 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12N 15/09 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2581969

It is intended to provide a regent for detecting cancer cells or diagnosing cancer. More specifically speaking, a reagent for detecting cancer cells containing a recombinant virus in which a replication cassette having a human telomerase promoter, E1A gene, IRES sequence and E1B gene in this order is integrated into the E1 region of the virus genome while a labeling cassette having a gene encoding a labeled protein and a promoter capable of regulating the expression of the gene is integrated into the E3 region of the virus genome.

Cette invention concerne un réactif destiné à détecter des cellules cancéreuses ou à diagnostiquer un cancer. Plus précisément, elle concerne un réactif visant à détecter des cellules cancéreuses, contenant un virus recombinant dans lequel une cassette de réplication possédant un promoteur de la télomérase humaine, le gène E1A , une séquence IRES et le gène E1B, dans cet ordre, est intégrée à la région E1 du génome du virus, tandis qu~une cassette de marquage avec un gène codant une protéine marquée et un précurseur capable de réguler l~expression du gène est intégrée à la région E3 du génome du virus.

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