Telomerase inhibitors

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/409 (2006.01) A61K 31/00 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 487/22 (2006.01)

Patent

CA 2360232

Telomerase inhibitors containing as the active ingredient porphyrin derivatives represented by general formula (I), N-(lower alkyl)-substituted derivatives thereof (wherein the lower alkyl is located on the nitrogen atom of the pyrrole ring of the porphyrin ring) or metal coordinates thereof or pharmacologically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and each represents hydrogen, formyl, optionally substituted lower alkyl, optionally substituted lower alkenyl, carboxy, optionally substituted lower alkoxycarbonyl, CONR9R10 (wherein R9 and R10 are the same or different and each represents hydrogen or optionally substituted lower alkyl), sulfo, lower alkoxysulfonyl or cyano.

La présente invention concerne des inhibiteurs de télomérase contenant, comme principe actif, des dérivés de porphyrine représentés par la formule générale (1) suivante, des dérivés à substituants N-(alkyle inférieur) de ces derniers (dans lesquels l'alkyle inférieur est situé sur l'atome d'azote du cycle pyrrole du cycle porphyrine) ou des composés métalliques coordonnés ou des sels pharmacologiquement acceptables de ces derniers : (1) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿ et R?8¿ sont les mêmes ou différents, chacun représentant un hydrogène, un formyle, un alkyle inférieur facultativement substitué, un alcényle inférieur facultativement substitué, un carboxy, un alcoxycarbonyle facultativement substitué, CONR?9¿R?10¿ (où R?9¿ et R?10¿ sont les mêmes ou différents, chacun représentant un hydrogène ou un alkyle inférieur facultativement substitué), un sulfo, un alcoxysulfonyle inférieur ou un cyano.

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