Telomerase inhibitors and methods of their use

Details Telomerase inhibitors and methods of their use Telomerase inhibitors and methods of their use

C - Chemistry, Metallurgy

07

D

C07D 277/34 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) C07D 277/36 (2006.01) C07D 417/06 (2006.01) C07D 417/10 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2341253

Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity <i>in vitro</i> and treatmnet of telomerase mediated conditions or diseases <i>ex vivo</i> and <i>in vivo</i> are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.

L'invention porte sur des composés de thiazolidinedione, sur des compositions, et sur des procédés d'inhibition de l'activité de la télomérase <i>in vitro</i> et sur le traitement des états ou maladies induits par la télomérase <i>ex vivo</i> et <i>in vivo</i>. Les procédés, composés et compositions de l'invention peuvent être utilisés seuls, ou en combinaison avec d'autres agents actifs d'un point de vue pharmacologique dans le traitement d'états ou maladies induits par l'activité de la télomérase, par exemple dans les traitements anticancéreux. L'invention porte également sur de nouvelles méthodes de dosage ou recherche systématique des inhibiteurs de l'activité de la télomérase.

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