C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C12N 5/078 (2010.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 17/02 (2006.01)
Patent
CA 2683454
According to the present invention, peptides comprising the amino acid sequence of SEQ ID NO: 3, 4, 9, 23, 25, 30, 60, 63 or 68 were demonstrated to have cytotoxic T lymphocyte (CTL) inducibility. Therefore, the present invention provides a peptide having the amino acid sequence selected from the group of SEQ ID NOs: 3, 4, 9, 23, 25, 30, 60, 63 and 68. The peptide can include one, two, or several amino acid substitutions or addition so long as its CTL inducibility is retained. Furthermore, the present invention provides pharmaceutical agents for treating and/or prophylaxis of tumors, and/or prevention of postoperative recurrence thereof, which comprises any of these peptides. The pharmaceutical agents of this invention include vaccines.
Selon la présente invention, il a été démontré que des peptides comprenant une séquence d'acides aminés SEQ ID NO : 3, 4, 9, 23, 25, 30, 60, 63 ou 68 font preuve d'une activité induisant les CTL (lymphocytes T cytotoxiques). La présente invention concerne donc un peptide comprenant une séquence d'acides aminés choisie dans le groupe constitué des séquences SEQ ID NO : 3, 4, 9, 23, 25, 30, 60, 63 et 68. Ledit peptide peut contenir une, deux ou plusieurs substitutions ou additions aminoacides, tant que son activité d'induction des CTL est conservée. La présente invention concerne en outre des agents pharmaceutiques destinés à traiter et/ou prévenir les tumeurs et/ou prévenir leur récurrence postopératoire, lesdits agents contenant l'un quelconque des peptides selon l'invention. Les agents pharmaceutiques de la présente invention peuvent notamment être des vaccins.
Osawa Ryuji
Tsunoda Takuya
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
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