Temperature-regulated culture plates

Details Temperature-regulated culture plates Temperature-regulated culture plates

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 5/00 (2006.01)

Patent

CA 2641550

Described herein are environmentally isolated tissue culture devices that may be used for cell culture, as well as systems including these devices and methods for using them. These devices may include control features for regulating the micro-environment within a well or wells of the device. For example, on-board features may regulate the temperature, humidity, pH, media level, media composition, CO2/O2/N2 levels, drug concentration, cell density, byproduct (or product) production, and mixing of materials within the chamber. Material may be added to or withdrawn from the wells of the device without opening the device. Also described herein are controllers for analyzing and controlling the micro- environment within the well. Thus, the plates described herein may be used without requiring a separate incubator, allowing cells to be analyzed (e.g., imaged) continuously, allowing real-time reactions while monitoring under a microscope for hours, days or even weeks.

L'invention concerne des dispositifs de culture de tissus isolés de l'environnement, pouvant être employés pour la culture cellulaire, ainsi que des systèmes comportant ces dispositifs et des procédés d'utilisation de ceux-ci. Les dispositifs selon l'invention peuvent comporter des éléments de commande destinés à réguler le micro-environnement dans un ou plusieurs puits du dispositif. Par exemple, des éléments intégrés permettent de réguler la température, l'humidité, le pH, le niveau du fluide, la composition du fluide, les niveaux de CO2/O2/N2, la concentration en médicament, la densité cellulaire, la production de produits secondaires ou de produits, et le mélange de substances dans la chambre. Des substances peuvent être additionnées ou retirées des puits du dispositif sans ouvrir le dispositif. L'invention concerne également des contrôleurs destinés à analyser et contrôler le micro-environnement dans le puits. Les plaques selon l'invention peuvent être employées sans requérir un incubateur séparé de manière à permettre une analyse (par ex. imagerie) continue des cellules, et des réactions en temps réel lors du contrôle au microscope, sur plusieurs heures, jours ou semaines.

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