Temperature regulated gene expression

Details Temperature regulated gene expression Temperature regulated gene expression

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C12N 1/21 (2006.01) C12N 9/22 (2006.01) C12N 15/55 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2550133

A method for regulation of gene expression by variation of temperature uses a riboswitch. The riboswitch includes a 5'-UTR construct of crhC which alters its secondary structure in response to temperature, resulting in a more stable transcript at lower temperatures, permitting translation. At higher temperatures, the transcript is destabilized and functionally inactive. The 5'-UTR construct of crhC may be operatively linked to a promoter and a gene and administered to cells with an expression vector.

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