Temperature sensitive and non-pathogenic bovine adenovirus

Details Temperature sensitive and non-pathogenic bovine adenovirus Temperature sensitive and non-pathogenic bovine adenovirus

C - Chemistry, Metallurgy

12

N

167/130

C12N 5/00 (2006.01) A61K 39/12 (2006.01) A61K 39/235 (2006.01) C12N 7/00 (2006.01) C12N 15/01 (2006.01)

Patent

CA 1039186

ABSTRACT OF THE DISCLOSURE The invention relates to the preparation of temperature-sensitive and substantially non-pathogenic bovine Adenovirus, more particularly Adeno 3 virus, strains by mutagenesis with nitrous acid. The temperature-sensitive strains have a cut-off temperature comprised between 39 and 40°C and are valuable for the preparation of vaccines which are administered by intranasal route.

199628

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