A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) C07K 14/435 (2006.01)
Patent
CA 2754461
Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposi-tion or accumulation of one or more ECM components.
L'invention concerne des enzymes métalloprotéase matricielle modifiée (MMP) dont l'activité dépend de la température, ainsi que leurs utilisations. Les MMP peuvent être utilisées, par exemple, pour traiter des maladies ou des troubles induits par ECM, qui sont caractérisées par un dépôt ou une accumulation accrus d'un ou de plusieurs composants ECM.
Bookbinder Louis
Chang Hwai Wen
Frey Gerhard Johann
Frost Gregory I.
Keller Gilbert A.
Halozyme Inc.
Smart & Biggar
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