Templated open flocs of anisotropic particles for enhanced...

A - Human Necessities – 61 – K

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A61K 9/72 (2006.01) A61K 9/14 (2006.01) A61K 31/49 (2006.01) A61K 31/496 (2006.01) A61K 38/16 (2006.01) A61K 39/39 (2006.01) A61K 39/395 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2723314

The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floe compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.

La présente invention concerne des compositions et des procédés de traitement et dadministration de préparations médicinales à laide dun inhalateur. La composition comprend une suspension floculée à espace rempli ayant une ou plusieurs particules floculées dun ou plusieurs agents actifs et un propulseur à base dhydrofluoroalcane. Une partie de la ou des particules floculées est divisée par la formation de gouttelettes dhydrofluoroalcane au moment de latomisation et le flocon divisé se resserre au moment de lévaporation du propulseur à base dhydrofluoroalcane pour former une particule poreuse pour une administration aux poumons en profondeur.

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