Temporary embolization using inverse thermosensitive polymers

Details Temporary embolization using inverse thermosensitive polymers Temporary embolization using inverse thermosensitive polymers

A - Human Necessities

61

L

A61L 31/04 (2006.01) A61B 17/00 (2006.01) A61B 17/03 (2006.01) A61K 31/74 (2006.01) A61K 49/00 (2006.01) A61K 51/06 (2006.01) A61L 31/16 (2006.01) A61L 31/18 (2006.01)

Patent

CA 2519946

One aspect of the present invention relates to methods of embolizing a vascular site in a mammal comprising introducing into the vasculature of a mammal a composition comprising an inverse thermosensitive polymer, wherein said inverse thermosensitive polymer gels in said vasculature, which composition may be injected through a small catheter, and which compositions gel at or below body temperature. In certain embodiments of the methods of embolization, said composition further comprises a marker molecule, such as a dye, radiopaque, or an MRI-visible compound.

Un aspect de la présente invention se rapporte à des méthodes d'embolisation d'un site vasculaire chez un mammifère, qui consistent à introduire dans le système vasculaire d'un mammifère, une composition comprenant un polymère thermosensible réversible qui gèle dans ledit système vasculaire. Ladite composition peut être injectée par un petit cathéter, lesdites compositions gelant à une température égale ou inférieure à la température corporelle. Dans certaines formes de réalisation des méthodes d'embolisation, ladite composition comprend également une molécule marqueur, telle qu'un colorant, un composé de contraste ou un composé visible par IRM.

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