Terazosin monohydrochloride and processes and intermediate...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 405/14 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2143974

The present invention provides a non-solvated crystalline polymorph of terazosin monohydrochloride designated Form III and methods for its preparation.Also disclosed is terazosin monohydrochloride methanolate and processes for its production as well as processes for its conversion to other crystalline forms ofterazosin monohydrochloride.

La présente invention permet d'obtenir un agent polymorphe cristallisé non solvaté de type monochlorhydrate de térazosine, appelé forme III, avec les méthodes de préparation. On présente également le monochlorhydrate de térazosine-méthanolate, avec les méthodes de préparation, ainsi que les procédés pour le convertir en d'autres formes cristallisées de monochlorhydrate de térazosine.

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