Terazosin polymorph and pharmaceutical composition

Details Terazosin polymorph and pharmaceutical composition Terazosin polymorph and pharmaceutical composition

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/505 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2107382

A novel anhydrous crystalline polymorph of 1-(4-amino-6,7-dimethoxy-2- quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine monohydrochloride is disclosed, together with pharmaceutical formulations containing the compound. The novel polymorph exhibits a diminished food effect when administered to human subjects.

On présente un nouveau monochlorhydrate de 1-(4-amino-6,7-diméthoxy-2- quinazolinyl)-4-(2-tétrahydrofuroyl)pipérazine, polymorphe, anhydre, cristallisé, avec des formulations pharmaceutiques renfermant le composé. Le nouvel agent polymorphe exerce un effet alimentaire moindre lorsqu'il est administré à des humains.

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