Terbutaline ester derivatives

Details Terbutaline ester derivatives Terbutaline ester derivatives

C - Chemistry, Metallurgy

07

C

167/254, 260/473

C07C 65/24 (2006.01) A61K 31/24 (2006.01) A61K 31/375 (2006.01)

Patent

CA 1210021

Abstract New bronchospasmolytically active compounds exhibiting long duration:of action and reduced undesired side effects, of the structural formula Image and therapeutically acceptable salts thereof, in which formula R, R1 and R2 are as follows: R is selected from the group consisting of -C(CH3)3, Image R1 is selected from the group consisting of H and R2; R2 is selected from the group consisting of (a) Image ( b ) Image and Image (c) in which formulas R is selected from the group consisting of (a) ll; (b) Image wherein R5 is a straight or branched alkyl group con- taining 1-4 carbon atoms and Image (c) and wherein R4 is selected from the group consisting of (a) H (b) an alkyl group containing 1-3 carbon atoms, process for the preparation thereof, chemical inter- mediates at their preparation, pharmaceutical compositions containing them and their medicinal use.

381320

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