Terephthalamide peptidomimetic compounds and methods

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 229/08 (2006.01) A61K 31/195 (2006.01) A61K 31/24 (2006.01)

Patent

CA 2556447

The present invention relates to compounds and pharmaceutical compositions based upon terephthalamide which are proteomimetic and to methods for inhibiting the interaction of an alpha-helical protein with another protein or binding site. Methods for treating diseases or conditions which are modulated through interactions between alpha helical proteins and their binding sites are other aspects of the invention. Methods of inhibiting the binding of proteins to their binding sites are other aspects of the present invention.

La présente invention concerne des composés et des compositions pharmaceutiques à base de téréphtalamide qui sont des protéomimétiques, ainsi que des méthodes destinées à l'inhibition de l'interaction entre une protéine alpha-hélicoïdale et une autre protéine ou un site de liaison. L'invention concerne également des méthodes destinée au traitement de maladies ou de troubles qui sont modulés par les interactions entre les protéines alpha-hélicoïdales et leurs sites de liaison. La présente invention concerne également des méthodes permettant d'inhiber la liaison des protéines au niveau de leurs sites de liaison.

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