Terminal sterilization of prefilled containers

A - Human Necessities – 61 – L

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A61L 2/08 (2006.01)

Patent

CA 2548715

A method for inhibiting adverse reaction of the contents of a prefilled container during a radiation sterilization procedure is disclosed. In the method, a container which is made of a material including a radiation stable polyolefin is prefilled with a medium prior to being subjected to a gamma irradiation sterilization treatment. By using a radiation stable polyolefin material as the container, such as a polyolefin with a radiation stabilizer additive, and by prefilling the container prior to the gamma irradiation treatment, the container can be effectively sterilized without adversely affecting its contents.

La présente invention se rapporte à un procédé permettant d'inhiber la réaction indésirable du contenu d'un contenant prérempli au cours d'une procédure de radiostérilisation. Selon ce procédé, un contenant qui est composé d'une matière incluant une polyoléfine stable vis-à-vis du rayonnement est prérempli avec un milieu avant d'être soumis à un traitement de stérilisation par exposition à un rayonnement gamma. Le fait d'utiliser pour le contenant une matière polyoléfinique, stable vis-à-vis des rayonnements, telle qu'une polyoléfine associée à un additif de stabilisation vis-à-vis des rayonnements, et le préremplissage du contenant avant le traitement par exposition au rayonnement gamma, permettent une stérilisation efficace du contenant sans modification indésirable de son contenu.

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