Terminally blocked antiviral peptides

Details Terminally blocked antiviral peptides Terminally blocked antiviral peptides

C - Chemistry, Metallurgy

07

K

C07K 5/097 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/12 (2006.01) C07K 5/078 (2006.01) C07K 7/64 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2077088

2077088 9113088 PCTABS00007 The invention relates to antiviral peptide compounds and to methods of inhibiting infection of human cells by viruses. This invention pertains more specifically to peptides that are chemically blocked at the amino- and carboxy-termini. In particular the invention relates to peptides comprised of prolylalanine or prolylphenylalanine compounds that have antiviral activity. The invention is specifically directed to methods for preventing infection of human cells in vivo and in vitro with the human immunodeficiency virus HIV-1 and methods for treating human infected with this and other viruses. The invention also relates to the diagnostic and therapeutic use of these antiviral peptide compounds.

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