C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/22 (2006.01) A61K 31/335 (2006.01) A61K 47/48 (2006.01) C07D 305/14 (2006.01) C07D 317/70 (2006.01) C08G 65/329 (2006.01) C08G 65/333 (2006.01)
Patent
CA 2437989
Terminally-branched polymeric prodrug platforms capable of high degrees of loading are disclosed. In preferred aspects of the invention, the prodrug platform releases multiple parent compounds after each branch holding the active agent undergoes a benzyl elimination reaction. Methods of preparing the prodrugs and using the same in the treatment of mammals are also disclosed. In one preferred aspect, polymeric conjugates such as (I) are provided.
La présente invention concerne des plates-formes de promédicaments polymères aux terminaisons ramifiées capables de degrés élevés de chargement. Sous des aspects préférés de l'invention, la plate-forme promédicamenteuse libère plusieurs composés parents après débenzylation de chaque ramification portant l'agent actif. L'invention concerne également des procédés permettant l'élaboration des promédicaments et leur utilisation dans des traitements destinés à des mammifères. Sous un aspect préféré, l'invention concerne des conjugués polymères tels qu'en (I).
Choe Yun Hwang
Greenwald Richard B.
Enzon Inc.
Macrae & Co.
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