C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/50 (2006.01) A61K 51/04 (2006.01) A61K 51/08 (2006.01) C07B 59/00 (2006.01) C07F 13/00 (2006.01) C07H 5/06 (2006.01) C07H 13/08 (2006.01) C07K 5/02 (2006.01) C07K 5/103 (2006.01) C07K 7/02 (2006.01) C07K 7/06 (2006.01) C07K 7/64 (2006.01) C07K 14/745 (2006.01)
Patent
CA 2404290
This invention relates to novel highly functionalized phosphine ligands as ancillary ligands in radiopharmaceuticals. Also, this invention provides radiopharmaceuticals comprised of highly functionalized phosphine ligated 99mTc labeled HYNIC-conjugated biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The invention also provides methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer.
La présente invention concerne de nouveaux ligands de phosphine hautement fonctionnalisés sous forme de ligands auxiliaires dans des produits radiopharmaceutiques. Cette invention concerne aussi des produits radiopharmaceutiques constitués de biomolécules conjuguées HYNIC marquée ?99m¿Tc et ligaturées à la phosphine hautement fonctionnalisée, qui se localisent sélectivement au niveau de sites de maladie et qui permettent ainsi d'obtenir une image des sites actifs par gammascintigraphie. Cette invention concerne enfin des techniques d'utilisation de ces produits radiopharmaceutiques sous forme d'agents d'imagerie destinés au diagnostic de pathologies cardio-vasculaires telles que les maladies thromboemboliques, l'athérosclérose, les maladies infectieuses et le cancer.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
LandOfFree
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