Terpene-quinone with antitumor activity

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 50/14 (2006.01) C07C 39/225 (2006.01) C07C 43/188 (2006.01) C07C 45/69 (2006.01) C07C 46/00 (2006.01) C07C 49/653 (2006.01) C07C 50/32 (2006.01) C07C 61/35 (2006.01) C07C 69/017 (2006.01) C07C 69/757 (2006.01) C07C 217/94 (2006.01) C07C 225/30 (2006.01) C07D 303/16 (2006.01)

Patent

CA 2173157

Terpene-quinone with antitumor activity defined from a cyclocondensation reaction of Diels-Alder, used to obtain families or series of said compounds having a new structure and presenting a cytotoxic activity to cellular cultures P-388, A-549, HT-29 and MEL-28, with levels of IC50 lower than 1 microgram per unit of millilitre.

Terpène-quinone avec activité antitumorale, définies à partir d'une réaction de cyclocondensation de Diels-Alder, permettant d'obtenir des familles ou séries de composés ayant une nouvelle structure et présentant une activité cytotoxique sur les cultures cellulaires P-388, A-549, HT-29 et MEL-28, atteignant des niveaux de IC¿50? inférieurs à 1 microgramme par unité de millilitre.

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