C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 271/10 (2006.01) A61K 31/4245 (2006.01) A61P 25/28 (2006.01) C07D 405/04 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/06 (2006.01) C07D 451/02 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2594946
The present invention is directed to tertiary carbinamine compounds having substituted heterocycles, which are inhibitors of the beta-secretase enzyme, and are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta- secretase enzyme is involved.
La présente invention concerne des dérivés de carbinamines tertiaires incluant des hétérocycles substitués, agissant en tant qu'inhibiteurs de l'enzyme bêta-secrétase, et pouvant être employés dans le traitement de maladies dans lesquelles ladite enzyme est impliquée, telles que la maladie d'Alzheimer. La présente invention concerne également des compositions pharmaceutiques comprenant lesdits composés, ainsi que l'emploi desdits composés et compositions dans le traitement de maladies dans lesquelles l'enzyme bêta-secrétase est impliquée.
Mcgaughey Georgia B.
Nantermet Philippe G.
Rajapakse Hemaka A.
Stauffer Shaun R.
Merck & Co. Inc
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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