C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2101774
Model systems of Alzheimer's disease comprise a DNA sequence encoding an amy-loid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be other than valine at the amino acid position corresponding to amino acid residue position 717 of APP770. Methods of determining genetic predisposi-tion to Alzheimer's disease are also disclosed.
Chartier-Harlin Marie-Christine
Goate Alison M.
Hardy John A.
Mullan Michael J.
Owen Michael J.
Elan Pharmaceuticals Inc.
Imperial College Of Science Technology & Medicine
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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