Test kit for tuberculosis diagnosis by determining alanine...

Details Test kit for tuberculosis diagnosis by determining alanine... Test kit for tuberculosis diagnosis by determining alanine...

C - Chemistry, Metallurgy

12

Q

C12Q 1/32 (2006.01) A61K 38/44 (2006.01) C12N 9/06 (2006.01) C12N 15/52 (2006.01) C12N 15/53 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2279255

Tuberculosis is an infectious disease which kills more than 3 million people every year. Although both a vaccine and various methods of diagnosis and treatment are available, the efficacy of these measures is in urgent need of improvement given that the number of new cases is once again on the increase. Research focuses, among other things, on the characterization of antigens secreted in the early stages of the infection as they constitute the first point of contact of the immune system with the pathogen. The 40 KD-antigen described in this article is present in vivo as a hexamer and, despite its high molecular weight and lack of a signal sequence, is present extracellularly after only a few days of growth. Functionally, it is an L-alanine dehydrogenase and reacts with the monoclonal antibody HBT-10 directed against this protein. HBT-10 was the first known antibody specific to a protein of M.tuberculosis which did not cross-react with the vaccine strain M.bovis BCG.

La tuberculose est une maladie infectieuse qui tue plus de 3 millions de personnes par an. Il existe un vaccin et différents procédés de diagnostic et de thérapie, mais, vu le nombre croissant de victimes, l'efficacité de toutes ces mesures nécessite une amélioration urgente. La recherche se concentre sur la caractérisation d'antigènes qui sont sécrétés de façon précoce lors d'une infection, puisque ces antigènes établissent le premier contact du système immunitaire avec l'agent infectieux. L'antigène de 40 kD dont il est question dans la présente étude se présente in vivo sous forme d'hexamère et, malgré un poids moléculaire élevé et l'absence d'une séquence-signal, on le trouve de façon extracellulaire déjà après quelques jours de croissance. Il constitue fonctionnellement une L-alanine déshydrogénase et réagit avec l'anticorps HBT-10 monoclonal dirigé contre cette protéine. HBT-10 fut le premier anticorps connu spécifique de la protéine de M. tuberculosis qui n'entre pas en réaction croisée avec la souche vaccinale M.bovis BCG.

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